Cue list of CYP3A inducers for increased conversion and excretion for faster/stronger onset and shorter overall duration. Or Preload with a 3A inducer and post load dose with an inhibitor for increased duration.
Without looking, I bet piperine/curcumin have potent enzymatic activity along these lines...
@SubstanceTheSqid Some dark humor...
Lethal Injestion?
Cue the potentiator slideshow:
There are some interesting potentiator combos that require care, especially with traditional opioids, most of which depress respiration...
Note that Kratom has been shown to NOT depress respiration, like traditional opioids or opiates do.
Death by Piperine & Curcuminoids?
Or maybe the dangerous potentiator grapefruit?
Medication interactions:
"Furanocoumarins in grapefruit have other biological effects as well. For example, in humans, bergamottin and 6',7'-dihydroxybergamottin are responsible for the "grapefruit juice effect", in which these furanocoumarins affect certain P450 liver and gut enzymes, such as the inhibition of CYP3A4 which either activates or deactivates many drugs, thus leading to higher or lower levels in the bloodstream. Furanocoumarins have various effects which can specifically increase or decrease (depending on the drug) the blood levels of many pharmaceuticals in ways that can be life-threatening and so FDA approved drugs will include warnings for grapefruit."
It's a scary world out there.....
And in my garden/farm. 🤯
For those without gooble handy and concerned about grapefruit contraindications, fresh lemon juice is a great replacement. Sweeten to taste, of course.
@roadkill I'll revisit this topic of 7-ohm enhancement again soon. I need to research the existing bentuangie papers and both videos on the fermentation and drying processes.
◇◇ work-in-progress◇◇